Natacha Karam was born in Jeddah, Saudi Arabia to mother Bernadette Devlin and father Marc Karam. Karam is of Lebanese and Northern Irish heritage. She spent most of her younger years in the middle east in Jordan,Jeddah, Bahrain, Dubai and Ireland. She moved to London shortly after turning eighteen to pursue a career in acting and attend art school. Karam believes that her inter-sectional cultures and her many 'homes' uniquely equip her to bring texture and humanity to the characters she portrays. She speaks